NMR spectroscopy (BioNMR) has become an indispensable method in structural biology. It has a long history, with Nobel Prizes awarded to Felix Bloch and Edward Purcell, 1952, Richard Ernst, 1991 & Kurt Wüthrich, 2002
). It plays an essential role in protein structure analysis and, generally, in structural biology.
At SARomics Biostructures, we offer custom peptide and protein NMR spectroscopy structure determination,
peptide NMR & protein NMR assignment, protein-ligand & protein-protein complex structure determination, epitope mapping, and dissociation constant (Kd) determinations for compounds, higher order structure (HOS) analysis of biosimilars and comparison with originator antibody, fragment library screening using 1D or 2D NMR. We can also offer expression and purification of 2H, 15N, and 13C-labelled proteins in E. coli
for NMR spectroscopy studies and structure determination.
Here we provide guidelines for NMR spectroscopy experiments. Many applications of NMR work around these conditions. For details of the services, please visit the services page, or enquire for advice on your project.