Structural Biology Services
Structural Biology Services
X-ray Crystallography, NMR Spectroscopy & Fragment-Based Lead Discovery
SARomics Biostructures is a CRO that provides a wide range of structural biology and drug discovery outsourcing services to the biotech industry and academic institutions. We have many years of experience and proven record of excellence in the fields of protein crystallization, X-ray crystallography, BioNMR spectroscopy, biophysical characterization of proteins, fragment screening and fragment-based drug discovery.
Please visit "about the company" for additional information or contact us directly for company presentation and discussion of your project.
To view our services packages please follow the links below.
Please visit "about the company" for additional information or contact us directly for company presentation and discussion of your project.
To view our services packages please follow the links below.
Our X-ray crystallography services provide protein crystallization and X-ray structure determination, FastLane™ Premium and FastLane™ standard libraries of verified drug targets (off-the-shelf structures), custom gene-to-structure and protein-ligand complex X-ray structure determination & structure-based lead discovery.
We provide a broad range of custom NMR (BioNMR) spectroscopy services that include peptide, protein, protein-ligand & protein-protein complex NMR assignment and 3D structure determination, NMR fragment screening using 1D or 2D NMR, epitope mapping and dissociation constant (Kd) determinations for compounds.
Antibody and antibody-antigen complex crystallization and high resolution X-ray structure determination, BioNMR and crystallographic characterization of higher order structure (HOS) of biosimilars, comparison with originator antibody and formulation optimization, biophysical characterization of antibodies and biosimilars in solution.
Integrated lead discovery and structure-based drug design (SBDD) including fragment screening, hit identification, hit to lead and lead optimization services, proprietary fragment library, weak-affinity chromatography screening.
High throughput (2000-3000 cmpds/week), robust and accurate (validated against NMR and X-ray) fragment screening using weak-affinity chromatography (WAC™), which also includes binding assay and measurement of fragment affinity to immobilized protein - all in one experiment!
Protein optimization and structure-based design of biological drugs (biologics) and peptides using quantitative structure-activity relationships (QSAR) methodology as implemented in our proprietary ProPHECY™ protein optimization software package.
State-of-the-art Structural Biology Services Platform
Our structural biology services platform is equipped with state-of-the-art instrumentation for protein production, robotic nanoliter-scale crystallization screening, robotic optimization of conditions for crystal growth and crystallization drop imaging. For X-ray data collection we use MAX IV synchrotron radiation facility, which is located a couple of kilometres from our labs in Lund. Alternatively, we send the crystals to other European synchrotrons. We collect X-ray data approximately every second week.
For NMR spectroscopy services we have access to high-quality, cutting-edge instrumentation. We provide de novo NMR protein structure determination, protein-ligand/protein-protein complex NMR structure determination, small molecule fragment library screening and much more…
You may visit our learning center for an overview of the experimental technologies we use in protein crystallization and X-ray crystallography, NMR spectroscopy and drug discovery & design services. Our recent blog post also discusses structural biology and drug discovery.
For NMR spectroscopy services we have access to high-quality, cutting-edge instrumentation. We provide de novo NMR protein structure determination, protein-ligand/protein-protein complex NMR structure determination, small molecule fragment library screening and much more…
You may visit our learning center for an overview of the experimental technologies we use in protein crystallization and X-ray crystallography, NMR spectroscopy and drug discovery & design services. Our recent blog post also discusses structural biology and drug discovery.
Serving the community since 2006!
Each year our platform handles on average over 100 new contract research projects within the field of Structural Biology. We worked with nearly all large pharmaceutical companies and more than 100 biotech companies and academic groups. Currently we have deposited more than 500 disclosable PDB X-ray and NMR spectroscopy structures.
And probably the best testimonials anybody can get: we have contributed to more than 240 co-authored structural papers published in leading journals like Nature, Nature Commun., J Biol Chem, J. Synchrotron Rad., PNAS, J Med Chem, JACS, etc.
To discuss your project with us please use the form below!
And probably the best testimonials anybody can get: we have contributed to more than 240 co-authored structural papers published in leading journals like Nature, Nature Commun., J Biol Chem, J. Synchrotron Rad., PNAS, J Med Chem, JACS, etc.
To discuss your project with us please use the form below!
Visit our Proteinshop!
Many of our FastLane™ Premium proteins can also be purchased as high-purity crystallization-grade samples for analytical purposes!
Many of our FastLane™ Premium proteins can also be purchased as high-purity crystallization-grade samples for analytical purposes!