Structural Biology Services

X-ray Crystallography, NMR Spectroscopy & Fragment-Based Drug Discovery

SARomics Biostructures is a contract research organization (CRO) that provides a wide range of structural biology outsourcing services to the biotech industry and academic institutions. We have many years of expertize and proven record of excellence in the fields of crystallization of proteins and protein-ligand complexes, structure determination by X-ray crystallography and BioNMR spectroscopy, biophysical characterization of proteins, fragment screening and ligand discovery.

Please visit "about the company" for additional information or contact us directly for company presentation and discussion of your project.

To view our services packages please follow the links below.

X-ray crystallography

protein X-ray crystallography services, gen-to-structure and off-the-shelf structures
Our X-ray crystallography services include FastLane™ Premium and FastLane™ standard libraries of verified drug targets (off-the-shelf structures), custom gene-to-structure and protein-ligand complex X-ray structure determination.

Protein NMR spectroscopy

protein NMR spectroscopy services, fragment screening and ligand binding
A broad range of custom protein NMR (BioNMR) spectroscopy services for peptide and protein structure analysis and fragment library screening.

Antibody structure characterization

antibody and antibody-antigen complex strucure charaterization, high order structure of biosimilars
Antibody structure characterization including crystallization and X-ray structure determination of antibodies, biosimilars' higher order structure (HOS) and antibody-antigen complexes.

Integrated lead discover

integrated drug discovery services
Integrated lead discovery and structure-based drug design (SBDD) including fragment screening, hit identification, hit to lead and lead optimization services, proprietary fragment library, weak-affinity chromatography screening.

WAC™ fragment screening

weak-affinity chromatography, fragment-based drug design
High throughput (2000-3000 cmpds/week), robust and accurate (validated against NMR and X-ray) fragment screening using weak-affinity chromatography (WAC™), which also includes binding assay and measurement of fragment affinity to immobilized protein - all in one experiment!

QSAR optimization of proteins

computational chemistry services, in silico screening and drug design
Protein optimization and structure-based design of biological drugs (biologics) and peptides using quantitative structure-activity relationships (QSAR) methodology as implemented in our proprietary ProPHECY™ protein optimization software package.

Accelerating Discovery Through Structural Insight!

Serving the community since 2006!

Our structural biology platform is equipped with state-of-the-art instrumentation for X-ray crystallography, including protein production, robotic nanoliter-scale crystallization screening, robotic optimization of conditions for crystal growth and crystallization drop imaging. For X-ray data collection we use MAX IV synchrotron radiation facility, which is located a couple of kilometres from our labs in Lund. Alternatively, we send the crystals to other European synchrotrons. We collect X-ray data approximately every second week.

For NMR spectroscopy we have access to high-quality, cutting-edge instrumentation. We provide
de novo NMR protein structure determination, protein-ligand/protein-protein complex NMR structure determination as well as small molecule fragment library screening.

Each year our platform handles on average over 100 new contract research projects within the field of Structural Biology. We worked with nearly all large pharmaceutical companies and more than 100 biotech companies and academic groups. Currently we have deposited more than 500 disclosable PDB X-ray and NMR spectroscopy structures.

And probably the best testimonials anybody can get: we have contributed to more than 240 co-authored structural papers published in leading journals like Nature, Nature Commun., J Biol Chem, J. Synchrotron Rad., PNAS, J Med Chem, JACS, etc.

You may visit our learning center for an overview of the experimental technologies we use in protein crystallization and X-ray crystallography, NMR spectroscopy and drug discovery services.

To discuss your project, please, use the form below!

Welcome to visit our Proteinshop!

Many of our FastLane™ Premium proteins can also be purchased as high-purity crystallization-grade samples for analytical purposes!
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