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Here we present company news & various activities and discuss how we help customers accelerate their lead discovery projects!

Structure-Based Drug Design at Room Temperature

New insights show that room-temperature and multi-temperature crystallography may be used in the study of functionally important conformations. This can be used to reveal temperature-dependent differences in protein-ligand interactions, including unique binding poses and even new binding sites.

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Biosimilars: Why is NMR spectroscopy the best method for comparability assessment?

The third article in our series about therapeutic monoclonal antibodies focuses on structural characterization and comparability analysis of biosimilars. We discuss existing evidence that shows that NMR spectroscopy is far superior to other established methods for comparability assessment, like FTIR, UV and circular dichroism (CD) spectroscopy, and differential scanning calorimetry (DSC).

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Antibody structure and engineering: therapeutic monoclonal antibodies

The development of new drugs of biological origin, the majority of which are monoclonal antibodies, is a major focus of modern-day drug design. The information on monoclonal antibody three-dimensional structure, in combination with antibody engineering, plays a central role in this process and has opened the way for the rapidly growing field of monoclöonal antibody therapeutics.

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