TAK1 inhibitor secures € 950 million
Using an integrated drug discovery approach, first-in-class TAK1 kinase inhibitors were designed in a hit-to-lead program run in close cooperation between three partners, SARomics Biostructures, Red Glead Discovery, and Aqilion.
We are delighted to share the recent Aqilion TAK1 inhibitor program. The company secured an exclusive license and strategic research collaboration with Merck, worth up to EUR 950 million, for its pre-clinical TAK1 inhibitor program. TAK1 is one of the central mediators in the inflammation process. Targeting this protein could lead to new treatments for a wide range of autoimmune and inflammatory disease indications.
SARomics Biostructures and RG Discovery supported the Aqilion TAK1 inhibitor program early in the project. A successful application of structure-based drug design, compound synthesis, and evaluation was performed to develop these first-in-class kinase inhibitors. The positive outcome was made possible through close cooperation with Aqilion’s chemistry team, who knew how to drive this project forward from the start. Ultimately, the successful hit-to-lead program led to the development of novel patented first-in-class TAK1 inhibitors.
With two of the three partners on the same site, an integrated approach was made possible, including a fast design-make-test-analyze cycle, which saved time and increased efficiency. We are fortunate and proud to have been a part of Aqilion’s journey on this project — big congratulations to the Aqilion team for this significant achievement. We hope for a successful progression of the compounds through the clinical phase to the stage when they can impact patients. It is also good to see that innovative early-stage drug discovery is rising in Skåne (Medicon Valley, Greater Copenhagen region, the Öresund region).
Please visit our Fragment-Based Drug Design Services page for details on our available services. To follow our updates, connect with us on LinkedIn.
