synchrotron X-ray Crystallography in drug Discovery
We highlight a study conducted by the AstraZeneca team on synchrotron X-ray crystallography in drug discovery (Käck & Sjögren, 2024).
crystallographic fragment screening
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Crystallographic Fragment Screening In Drug Discovery: Background & Advantages
Technical developments have made crystallographic fragment screening the most effective method for screening fragment libraries. Here, we provide a brief overview of the method and its requirements.
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Protein-Ligand Interactions: Room Temperature or Cryo-Crystallography?
After many years of cryo-crystallography dominance, room-temperature X-ray crystallography using synchrotron radiation has returned. We discuss the application of room-temperature X-ray crystallography in drug design.
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How to Choose A Library for Screening?
In this third post on structural biology and structure-based drug design we discuss methods and benefits of fragment-based lead discovery
