Publications Co-Authored by SARomics Biostructures Team Members

2021

Beckmann R, Jensen K, Fenn S, Speck J, Krause K, Meier A, Röth M, Fauser S, Kimbung R, Logan DT, Steegmaier M & Kettenberger H. (2021).
DutaFabs: A novel platform of bispecific therapeutic Fab fragments which can simultaneously bind two targets with high affinity.
Nature Communications 12, 708.
https://doi.org/10.1038/s41467-021-20949-3

Stenström O, Diehl C, Modig K, Nilsson U J, and Akke M. (2021).
Mapping the energy landscape of protein–ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion.
RSC Chem. Biol. 2, 259-265.
https://doi.org/10.1039/D0CB00229A

Durcik M, et al. and
Welin M, Kimbung R, Focht D et al. and Tomašiča T. (2021).
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.
Eur J Med Chem 213, 113200.
https://doi.org/10.1016/j.ejmech.2021.113200

2019-2020

Lima GMA, Talibov VO, Jagudin E, Sele C, Nyblom M, Knecht W, Logan DT, Sjögren T & Mueller U (2020).
FragMAX: The fragment screening platform at the MAX IV Laboratory.
Acta Crystallogr. D Structural Biology 76, 771–777.
https://doi.org/10.1107/S205979832000889X

Nyerges A, et al. and
Welin M, Kimbung R, Focht D, Peterlin Mašič L, and Pal C. (2020).
Rational design of balanced dual-targeting antibiotics with limited resistance.
PLoS Biol 18(10):e3000819.
https://doi.org/10.1371/journal.pbio.3000819

Karczewski J, Krasucki S P, Asare-Okai P N, Diehl C, Friedman A, Brown C M, Maezato Y, and Streatfield S J. (2020).
Isolation, Characterization and Structure Elucidation of a Novel Lantibiotic From Paenibacillus sp.
Front. Microbiol. 24.
https://doi.org/10.3389/fmicb.2020.598789

Sanchez-Fernandez A,
Diehl C, Houston J E, Leung A E, Tellam J P, Rogers S E, Prevost S, Ulvenlund S, Sjögren H, and Wahlgren M. (2020).
An integrative toolbox to unlock the structure and dynamics of protein–surfactant complexes.
Nanoscale Adv 2, 4011-4023.
https://doi.org/10.1039/D0NA00194E

Schneider, P.,
Welin, M., Svensson, B., Walse, B. and Schneider, G. (2020)
Virtual screening and design with machine intelligence applied to Pim‐1 kinase inhibitors.
Mol. Inf., 39, 2000109.
https://doi.org/10.1002/minf.202000109

Telzerow A, Paris J,
Håkansson M, González‐Sabín J, Ríos‐Lombardía N, Gröger H, Morís F, Schürmann M, Schwab H, Steiner K. (2020).
Expanding the Toolbox of R‐Selective Amine Transaminases by Identification and Characterization of New Members.
ChemBioChem 2020 21, 1–12.
https://doi.org/10.1002/cbic.202000692

Ladds M J G W, Popova G, Pastor-Fernández A, Kannan S, van Leeuwen I M M,
Håkansson M, Walse B, Tholander F, Ravi Bhatia, Verma C S, Lane D P, Laín S. (2020).
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
J Biol Chem 295, 17935-17949.
https://doi.org/10.1074/jbc.RA119.012056

Shilova A, Lebrette H, Aurelius, O, Nan J,
Welin M, Kovacic R, Ghosh S, Safari C, Friel R J, Milas M, Matej Z, Högbom M, Brändén G, Kloos M, Shoeman R L, Doak B, Ursby, T M. Håkansson T M, Logan D T, and Mueller U. (2020).
Current status and future opportunities for serial crystallography at MAX IV Laboratory
J. Synchrotron Rad. 27, 1095-1102.
https://doi.org/10.1107/S1600577520008735

Plotka M, Szadkowska M,
Håkansson M, Kovačič R, Al-Karadaghi S, Walse B, Werbowy O, Kaczorowska A-K, and Kaczorowski T. (2020).
Molecular Characterization of a Novel Lytic Enzyme LysC from Clostridium intestinale URNW and Its Antibacterial Activity Mediated by Positively Charged N-Terminal Extension.
Int J Mol Sci. 21, 4894;
https://doi.org/10.3390/ijms21144894

Baggio C, Udompholkul P, Gambini L, Jossart J, Salem AF,
Håkansson M, Perry JJP, Pellecchia M. (2020)
N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists.
Chem Biol Drug Des. 95, 412-426.
doi: 10.1111/cbdd.13661
The crystal structure of the complex between N‐locked covalent peptide and Bfl‐1 determined here, provided insights on the geometry of the N‐locking strategy and of the covalent bond between the agent and Bfl‐1.

Telzerow A, Paris J,
Håkansson M, Gonzalez-Sabin J, Rios-Lombardía N, Schrmann M, Grger H, Morís F, Kourist R, Schwab H and Steiner K (2019).
Amine Transaminase from Exophiala Xenobiotica
- Crystal Structure and Engineering of a Fold IV Transaminase that Naturally Converts Biaryl Ketones.
ACS Catal. 9, 1140−1148. https://doi.org/10.1021/acscatal.8b04524

Dahlqvist A, Mandal S, Peterson K,
Håkansson M, Logan DT, Zetterberg FR, Leffler H, Nilsson UJ (2019).
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3.
Molecules. 24 (24), 4554. https://doi.org/10.3390/molecules24244554

Ruggieri F, Campillo-Brocal JC, Chen S, Humble MS,
Walse B, Logan DT, Berglund P (2019).
Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase.
Sci Rep. 9, 16946. DOI: 10.1093/nar/25.17.3389

Freitag-Pohl S, Jasilionis A,
Håkansson M, Svensson LA, Kovačič R, Welin M, Watzlawick H, Wang L, Altenbuchner J, Płotka M, Kaczorowska AK, Kaczorowski T, Nordberg Karlsson E, Al-Karadaghi S, Walse B, Aevarsson A, Pohl E (2019).
Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS.
Acta Crystallogr D Struct Biol., 75(Pt 11):1028-1039. https://doi.org/10.1107/S2059798319013330

Korkmaz B, Lesner A, Wysocka M, Gieldon A,
Håkansson M, Gauthier F, Logan DT, Jenne DE, Lauritzen C, Pedersen J (2019).
Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.
Biochem Pharmacol. 164, 349-367.
https://doi.org/10.1016/j.bcp.2019.04.006

Kracht ON, Correia Cordeiro RS,
Håkansson M, Stockmann J, Sander D, Bandow J, Senges CHR, Logan DT, Kourist R (2019).
Discovery of three novel sesquiterpene synthases from Streptomyces chartreusis NRRL 3882 and crystal structure of an α-eudesmol synthase.
J Biotechnol. 297, 71-77. https://doi.org/10.1016/j.jbiotec.2019.03.006

Casaletto JB, Geddie ML, Abu-Yousif AO, Masson K, Fulgham A, Boudot A, Maiwald T, Kearns JD, Kohli N, Su S, Razlog M, Raue A, Kalra A,
Håkansson M, Logan DT, Welin M, Chattopadhyay S, Harms BD, Nielsen UB, Schoeberl B, Lugovskoy AA, MacBeath G (2019).
MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Proc Natl Acad Sci U S A 116, 7533-7542. https://doi.org/10.1073/pnas.1819085116

2017-2018

Ruggieri F, van Langen LM, Logan DT, Walse B, Berglund P. (2018).
Transaminase-Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions.
ChemCatChem, 10, 1-8. https://doi.org/10.1002/cctc.201801049

Gustafsson NMS, Färnegårdh K, Bonagas N, Ninou AH, Groth P, Wiita E, Jönsson M,
Hallberg K, Lehto J, Pennisi R, Martinsson J, Norström C, Hollers J, Schultz J, Andersson M, Markova N, Marttila P, Kim B, Norin M, Olin T, Helleday T (2018).
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Nat Commun. 9, 3872. DOI: 10.1038/s41467-018-06287-x

Abdillahi SM, Maaß T, Kasetty G, Strömstedt AA, Baumgarten M, Tati R, Nordin SL,
Walse B, Wagener R, Schmidtchen A, Mörgelin M (2018)
Collagen VI Contains Multiple Host Defense Peptides with Potent In Vivo Activity.
J Immunol., 201, 1007-1020. https://doi.org/10.4049/jimmunol.1700602

Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M,
Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S. A (2018).
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Nat Commun. 9, 1107. DOI: 10.1038/s41467-018-03441-3

Andersen MCF, Boos I, Kinnaert C, Awan SI, Pedersen HL, Kračun SK, Lanz G,Rydahl MG, Kjærulff L,
Håkansson M, Kimbung R, Logan DT, Gotfredsen CH, Willats WGT, Clausen MH (2018).
Synthesis of branched and linear 1,4-linked galactan oligosaccharides.
Org Biomol Chem. 16, 1157-1162. DOI: 10.1039/c7ob03035e

Peterson K, Kumar R, Stenström O, Verma P, Verma PR,
Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ (2018).
Systematic tuning of fluoro-galectin-3 interactions provides thiodigalactoside derivatives with single digit nM affinity and high selectivity.
J Med Chem 61, 1164–1175. DOI: 10.1021/acs.jmedchem.7b01626.

Zetterberg FR, Peterson K, Johnsson R, Brimert T,
Håkansson M, Logan DT, Leffler H, Nilsson UJ (2018).
Monosaccharide derivatives with low nM lectin affinity and high selectivity based on combined fluorine-amide, phenyl-arginine, sulfur-π, and halogen bond interactions.
ChemMedChem 13, 133-137. DOI: 10.1002/cmdc.201700744.

Takemoto Y, Slough DP, Meinke G, Katnik C, Graziano ZA, Chidipi B, Reiser M, Alhadidy MM, Ramirez R, Salvador-Montañés O, Ennis S, Guerrero-Serna G, Haburcak M,
Diehl C, Cuevas J, Jalife J, Bohm A, Lin YS, Noujaim SF (2017).
Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule.
FASEB J pii: fj.201700349R. DOI: 10.1096/fj.201700349R.

Anderson LC,
Håkansson M, Walse B and Nilsson CL (2017).
Intact Protein Analysis at 21 Tesla and X-Ray Crystallography Define Structural Differences in Single Amino Acid Variants of Human Mitochondrial Branched-Chain Amino Acid Aminotransferase 2 (BCAT2).
J Am Soc Mass Spectrom 28, 1796-1804. DOI: 10.1007/s13361-017-1705-0

Walse B, Turnbull AP and Boyd SM (2017).
Tailoring Hit Identification and Qualification Methods for Targeting Protein–Protein Interactions.
In Applied Biophysics for Drug Discovery (Huddler, D. and Zartler, E.R., ed.) pp. 29-59, John Wiley & Sons, Inc, Hoboken, NJ, USA.

Linares-Pastén JA, Falck P, Albasri K, Kjellström S, Adlercreutz P,
Logan DT & Nordberg Karlsson E (2017).
Three-dimensional structures and functional studies of two GH43 arabinofuranosidases from Weissella sp. strain 142 and Lactobacillus brevis.
FEBS J, May 9. DOI: 10.1111/febs.14101

Pippione AC, Federico A, Ducime A, Sainas S, Boschi D, Barge A, Lupino L, Piccinini M, Kubbutat M, Contreras J-M, Morice C, Al-
Karadaghi S and Lolli ML. (2017).
4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade.
Med. Chem. Commun. 8, 1850–1855. DOI: 10.1039/c7md00278e

Sainas S, Pippione AC, Giorgis M, Lupino E, Goyal P, Ramondetti C, Buccinnà B, Piccinini M, Braga RC, Andrade CH, Andersson M, Moritzer AC, Friemann R, Mensa S,
Al-Karadaghi S, Boschi D & Lolli ML (2017).
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.
Eur J Med Chem 129, 287-302. https://doi.org/10.1016/j.ejmech.2017.02.017

Kulkarni TS ,Khan S, Villagomez R, Mahmood T, Lindahl S,
Logan DT, Linares-Pastén JA & Nordberg Karlsson E (2017).
Crystal structure of β-glucosidase 1A from Thermotoga neapolitana and comparison of active site mutants for hydrolysis of flavonoid glucosides.
Proteins 85, 872-884. DOI:10.1002/prot.25256

Noresson AL, Aurelius O, Öberg CT, Engström O, Sundin AP, Håkansson M, Stenström O, Akke M, Logan DT, Leffler H, Nilsson UJ (2017).
Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.
Chem Sci. 9, 1014-1021. DOI: 10.1039/c7sc04749e

2015-2016

Nilsson LM, Green LC, Veppil Muralidharan S, Demir D, Welin M, Bhadury J, Logan D, Walse B and Nilsson JA (2016).
Cancer differentiating agent hexamethylene bisacetamide inhibits BET bromodomain proteins.
Cancer Res. 76, 2376-2383. DOI: 10.1158/0008-5472.CAN-15-2721

Badarau A, Rouha H, Malafa S, Battles MB, Walker L, Nielson N, Dolezilkova I, Teubenbacher A, Banerjee S, Maierhofer B, Weber S, Stulik L,
Logan DT, Welin M, Mirkina I, Pleban C, Zauner G, Gross K, Jägerhofer M, Magyarics Z & Nagy E (2016).
Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies.
MAbs. 8, 1347-1360. DOI: 10.1080/19420862.2016.1215791

Wang H, Lang L,
Logan DT, Danielsson J & Oliveberg M (2016).
Tricking a protein to swap strands.
J. Am. Chem. Soc. 138, 15571-15579. DOI: 10.1021/jacs.6b05151

Manzoni F, Saraboji K, Sprenger J, Noresson A-L, Nilsson U, Leffler H, Fisher Z, Schrader T, Ostermann A, Coates L, Blakeley MP, Oksanen O &
Logan DT (2016).
Perdeuteration, crystallisation, data collection and comparison of five neutron diffraction datasets of human galectin-3C.
Acta Crystallogr. D. Biol. Crystallogr. 72, 1194-1202. DOI:10.1107/S2059798316015540

Bågenholm V, Reddy SK, Bouraoui H, Morrill J, Kulcinskaja E, Bahr CM, Aurelius O, Rogerts T, Xiao Y,
Logan DT, Martens EC, Koropatkin NM & Stålbrand H (2016).
Galactomannan catabolism conferred by a polysaccharide utilisation locus of Bacteroides ovatus: enzyme synergy and crystal structure of a β-mannanase.
J. Biol. Chem. 292, 229-243. DOI: jbc.M116.746438

Sprenger J, Carey J,
Svensson B, Wengel V, Persson L (2016).
Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing.
PLoS One. 11:e0163442. DOI: 10.1371/journal.pone.0163442.

Badarau A, Rouha H, Malafa S, Logan DT, Håkansson M, Stulik L, Dolezilkova I, Teubenbacher A, Gross K, Maierhofer B, Weber S, Jägerhofer M, Hoffmann D, Nagy E (2015).
Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the Staphylococcus aureus Bi-component Toxin LukGH.
J. Biol. Chem. 290, 142-156. DOI: 10.1074/jbc.M114.598110

Rodrigues T, Reker, D,Welin M, Caldera M, Brunner C, Gabernet G,Schneider P,
Walse B and Schneider G (2015).
De Novo Fragment Design for Drug Discovery and Chemical Biology.
Angewandte Chemie International Edition, DOI: 10.1002/anie.201508055.

Fisher SZ, von Schantz L,
Håkansson M, Logan DT & Ohlin M. (2015).
Neutron Crystallographic Studies Reveal Hydrogen Bond and Water-Mediated Interactions between a Carbohydrate-Binding Module and Its Bound Carbohydrate Ligand.
Biochemistry 54, 6435-6438. DOI: 10.1021/acs.biochem.5b01058

Sprenger J,
Svensson B, Hålander J, Carey J, Persson L & Al-Karadaghi S (2015).
Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design.
Acta Cryst. D Biol Crystallogr. 71, 484-493. DOI: 10.1107/S1399004714027011

Jong-Eun Kim, Joe Eun Son, Hyein Jeong, Dong Joon Kim, Sang Gwon Seo, Eunjung Lee, Tae Gyu Lim, Jong Rhan Kim, Yengo Raymond Kimbung, Hanyong Chen, Ann M. Bode, Ki Won Lee and Zigang Dong (2015).
A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer.
Cancer Res. 75, 2716-2728.
doi: 10.1158/0008-5472.CAN-14-3655

2013-2014

von Schantz L, Håkansson M, Logan DT, Nordberg-Karlsson E and Ohlin M (2014).
Carbohydrate binding module recognition of xyloglucan defined by polar contacts with branching xyloses and CH-π interactions.
Proteins, 82, 3466-75.

Turnbull AP, Boyd SM & Walse B (2014).
Fragment-based drug discovery and protein-protein interactions.
Res. Rep Biochem. 4, 13-26.

Lolli ML, Ducime A, Federico, A Pippione AC, Sainas S, Barge A, Martina K, Boschi D, Lupino E, Piccinini M, Kubbutat M, Schächtele C, Contreras JM, Morice C, Sussman J, Peleg J, Walse B and Al-Kadaraghi S (2014).
Towards a Bioisosteric Alkaest: application to the bioisosteric modulation of IMD-0354.
In: Book of Abstracts. p. 234, Lisbon, Portugal, September 7-11.
See poster…

Lolli ML, Ducime A, Federico A, Pippione AC, Sainas S, Barge A, Martina K, Boschi D, Lupino E, Piccinini M, Kubbutat M, Schächtele C, Contreras JM, Morice C, Sussman J, Peleg J,
Walse B, Al-Kadaraghi S (2014).
Towards a Bioisosteric Alkaest: application to the bioisosteric modulation of IMD-0354.

In: Book of Abstracts. p. 100, San Diego, USA, April 23-25. See poster…

Contreras JM,
Svensson B, Walse B, Al-Karadaghi S, Totzke F, Kubbutat M, Schächtele C, Morice C, and Langer T. (2014).
Comparison of hit discovery approaches case study: NIK inhibitors. EFMC-ISMC 2014, XXIII International Symposium on Medicinal Chemistry, Lisbon, Portugal - September 7-11.
See poster...

Söderberg CA, Rajan S, Shkumatov AV, Gakh O, Schaefer S, Ahlgren EC, Svergun DI, Isaya G, Al-Karadaghi S. (2013).
The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization.
J Biol Chem., 288, 8156-67.

Danielsson J, Awad W, Saraboji K, Kurnik M, Lang L, Leinartaite L, Marklund SL,
Logan DT, Oliveberg M (2013).
Global structural motions from the strain of a single hydrogen bond.
Proc Natl Acad Sci U S A, 110, 3829-34.

Saraboji K, Håkansson M, Genheden S, Diehl C, Qvist J, Weininger U, Nilsson UJ, Leffler H, Ryde U,
Akke M & Logan DT. (2012).
The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics.
Biochemistry 2012, 51:296-306.

Humble MS, Cassimjee KE,
Håkansson, M, Kimbung YR, Walse B, Abedi V, Federsel H-J, Berglund P & Logan DT (2012).
Crystal structures of the Chromobacterium violaceum ω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP.
FEBS J., 279, 779-792.

von Schantz, L., Håkansson, M., Logan, D.T., Walse, B., Osterlin, J., Nordberg-Karlsson, E. and Ohlin, M. (2012).
Structural basis for carbohydrate-binding specificity -a comparative assessment of two engineered carbohydrate-binding modules.
Glycobiology, 22, 948-961.

Akke M (2012).
Conformational dynamics and thermodynamics of protein-ligand binding studied by NMR relaxation.
Biochem Soc Trans., 40, 419-23.

Boyd SM, Turnbull AP and
Walse B (2012).
Fragment library design considerations.
WIREs Comput. Mol. Sci., 2, 868-885.

Weininger U, Liu Z, McIntyre DD, Vogel HJ,
Akke M(2012).
Specific 12CβD(2)12CγD(2)S13CεHD(2) isotopomer labeling of methionine to characterize protein dynamics by 1H and 13C NMR relaxation dispersion.
J Am Chem Soc., 134, 18562-5.

2009-2011

Liljas A, Ehrenberg M, Åqvist J. (2011).
Comment on "The mechanism for activation of GTP hydrolysis on the ribosome".
Science. 2011, 333:37.

Wang E, Ikonen TP, Knaapila M, Svergun D,
Logan DT & von Wachenfeldt C. (2011).
Small-angle X-ray scattering study of a Rex family repressor: conformational response to NADH and NAD+ binding in solution.
J Mol Biol. 2011, 408:670-683.

Kasetty G, Papareddy P, Kalle M, Rydengård V,
Walse B, Svensson B, Mörgelin M, Malmsten M & Schmidtchen A (2011).
The C-terminal sequence of several human serine proteases encodes host defense functions.
J Innate Immun. 3, 471-482.

Logan DT (2011).
Closing the circle on ribonucleotide reductases.
Nat Struct Mol Biol. 2011, 18:251-253.

Svensson SL, Pasupuleti M, Walse B, Malmsten M, Mörgelin M, Sjögren C, Olin AI, Collin M, Schmidtchen A, Palmer R & Egesten A (2010).
Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution.
J Biol Chem. 285, 16105-16115.

Bernadó P, Modig K, Grela P, Svergun DI, Tchorzewski M, Pons M & Akke M (2010).
Structure and Dynamics of Ribosomal Protein L12: An Ensemble Model Based on SAXS and NMR Relaxation.
Biophys J. 98, 2374-2382.

Diehl C, Engström O, Delaine T, Håkansson M, Genheden S, Modig K, Leffler H, Ryde U, Nilsson UJ & Akke M (2010). Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3.
J Am Chem Soc. 132, 14577-1489.

Lundqvist J, Elmlund H, Peterson Wulff R, Berglund L, Elmlund D, Emanuelsson C, Hebert H, Willows RD, Hansson M, Lindahl M &
Al-Karadaghi S (2010).
ATP-induced conformational dynamics in the AAA+ motor unit of magnesium chelatase.
Structure 18, 354-365.

Fritzson I, Svensson B,
Al-Karadaghi S, Walse B, Wellmar U, Nilsson UJ, da Graça Thrige D & Jönsson S. (2010).
Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection.
ChemMedChem. 5, 608-617.

Teilum K, Smith MH, Schulz E, Christensen LC, Solomentsev G, Oliveberg M &
Akke M (2009).
Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization.
Proc Natl Acad Sci USA. 106, 18273-18278.

Nordlund A, Leinartaite L, Saraboji K, Aisenbrey C, Gröbner G, Zetterström P, Danielsson J,
Logan DT & Oliveberg M (2009).
Functional features cause misfolding of the ALS-provoking enzyme SOD1.
Proc Natl Acad Sci USA. 106, 9667-9672.