About the method
It is often desirable to modify a biomolecule (peptide, polypeptide, protein, antibody etc.) to optimize specific properties in a rational way. For example:
Our proprietary and proven ProPHECY™ in silico protein optimization technology offers a quick and less costly approach.
- increase its biological or catalytic activity
- decrease its antigenicity
- enhance its cell penetrating capabilities
- protease resistance,
- thermal stability,
By modifying and optimizing the amino acid sequence of a protein one could explore the structure-activity relationships (SAR) and using them control protein properties and eventually modify them in a desired way. ProPHECY™ is reminiscent of QSAR (Quantitative Structure-Activity Relationship) methodology used for decades in the optimization of organic small molecules. It uses a novel method by which experimentally determined properties of a protein can be utilized for the prediction of amino acid replacements required to achieve controlled modifications. This will greatly reduce effort, time and costs required in a protein optimization project. You are welcome to contact us for further discussion of your project.