Antibody Structure & Comparability Analysis Services

SARomics Biostructures' team has extensive experience in X-ray and NMR spectroscopic analysis of monoclonal antibody and antibody-antigen complex structures. Our services also include structural characterization and comparability studies of biosimilars' higher-order structure (HOS) using 13C-natural abundance 2D-NMR spectroscopy. All our studies include biophysical characterization of the state of the monoclonal antibodies and biosimilars in solution.

More detailed, our monoclonal antibody structure services can help you with the following:
  • Epitope definition to file stronger IP
  • Understanding the mode of action
  • Structure-based antibody engineering: affinity maturation, humanization, antibody-drug conjugates (ADC), etc.
  • Structural characterization of protein drugs for regulatory purposes

Please see our blog series on monoclonal antibodies and biosimilars for additional information. Our X-ray crystallography and NMR spectroscopy services platform is equipped to handle projects of all types, including challenging projects. To discuss your project, please do not hesitate to contact us.

For an overview of our services, please download the white paper below.

Festival of Biologics, October 2023

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On the image: Karin Kettisen (left) and Nadia Rose at the Festival of Biologics meeting, October 2023, Basel, Switzerland. Please follow the links to view the posters presented by Nadia and Karin.