Integrated drug discovery at SARomics Biostructures

Integrated Drug Discovery Services: Hit Identification and Hit-to-Lead Optimization

OVERVIEW

Our integrated drug discovery and
structure-based drug design (SBDD) platform offers library screening and fragment-based drug discovery (FBDD), including hit identification and hit-to-lead optimization for any target with known three-dimensional structure. Our team has gathered extensive expertise in compound screening, computational chemistry and structure-based drug discovery and drug design. In collaboration with our in-house partner Red Glead Discovery we offer expertise in drug development, including hit-to-lead compound optimization, assay development and biological characterization, medicinal chemistry and ADME.

The
gene-to-drug program includes protein cloning, expression, purification, crystallization of target proteins in complex with ligands and structure determination by X-ray crystallography. SARomics Biostructures' FastLane™ off-the-shelf gene-to-structure library, which contains almost 200 constructs, among which are kinases, phosphatases, epigenetic targets and other proteins, will provide substantial acceleration of your drug discovery project.

FBDD platform with full-range discovery services

Our experts will provide support in the design of the best hit identification and hit-to-lead design and optimization strategy. Our expertise and capabilities in computational chemistry, NMR spectroscopy and X-ray crystallography, thermal-shift assay (DSF), isothermal titration calorimetry (ITC) and Microscale thermophoresis (MST), are applied to ensure the most optimal and time-efficient process. The hit expansion and subsequent optimization programs are run in close collaboration with our partner Red Glead Discovery.

Please view a summary of the available options in the table below (
scroll down to see the whole list).

Biophysical screening methods


WAC™ screening technology

Our proprietary WAC™ (weak affinity chromatography) screening technology allows simultaneous identification of weak binders (mM-μM) in complex mixtures, as well as Kd calculation. Detection by LC-MS.

Other biophysical screening methods

The screening platform also uses a range of biophysical screening methods, which include in silico screening, thermal-shift assay (DSF), isothermal titration calorimetry (ITC), Microscale thermophoresis (MST), NMR spectroscopy and X-ray crystallography. in addition, it also offers high-concentration biochemical screening (HCS).


Fragment library

Proprietary library design for easy hit expansion, specifically ordered sets and client libraries. Please enquire for details.


Structural biology

Highly efficient structural biology platform and extensive experience in the use of structural data in hit expansion and lead optimization


Computational chemistry

Extensive experience in hit expansion, pharmacophore- and shape-based virtual screening, scaffold hopping, QSAR analysis and optimization


Medicinal chemistry

Through our collaboration with Red Glead we offer expertise in lead optimization, biological characterization, medicinal chemistry and ADME

The methods of computational chemistry can be efficiently applied to assist the drug discovery and drug design process. We offer our customers services in docking, library design and virtual screening of compound libraries, QSAR analysis, scaffold hopping, etc., see more

The combination of our proprietary WAC™ fragment screening method with our expertise in structure-based drug design and medicinal chemistry helps our clients to design the best strategy for the drug discovery project, see more