• Protein crystallization and X-ray crystallography
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    FastLane Premium off-the-shelf Protein Structures

    Fastlane Premium Structures

    FastLane Standrard  protein off-the-shelf structures

    Fastlane Standard Structures

    gene-to-structure services

    Gene-to-Structures Services

Crystallography Services: FastLane™ Premium Library

SARomics Biostructures FastLane™ Premium library of verified drug target protein structures (off-the-shelf structures) offers contract crystallization and X-ray structure determination services of ligand-protein complexes with turnaround time of 2 to 8 weeks. The library offers three-dimensional crystallographic structures of kinases, phosphatases, epigenetic targets and other proteins.

Please scroll down to view the entire list of available FastLane™ Premium X-ray structures

AR or Aldose reductase (a.a. 1-316)
ATAD2A - Bromodomain, ATPase family AAA domain-containing protein 2 (a.a. 981-1108)
ATAD2B - Bromodomain, ATPase family AAA domain-containing protein 2B, (a.a. 952-1086)

BCAT2 - Branched-chain-amino-acid aminotransferase, mitochondrial
Beta-lactamase - BlaC or Beta-lactamase (M. tuberculosis)
Bfl-1 - Bcl-2-related protein A1
BTK kinase - Tyrosine-protein kinase BTK

Cathepsin C - DPPI or Dipeptidyl peptidase 1
CLK3 - Dual specificity protein kinase CLK3
CK2 kinase - Casein kinase II subunit alpha

DAPK3 kinase - Death-associated protein kinase 3
DHODH - Dihydroorotate dehydrogenase (human)
DPP4 - Dipeptidyl peptidase 4

EphA7 kinase - Ephrin type-A receptor 7

Gal-3C - Galectin-3 carbohydrate recognition domain
Gal-8 - N-terminal domain of human galectin-8
GMPR2 - GMP reductase 2

HSP90 - Heat shock protein HSP 90-alpha
HER2 - Extracellular domain (a.a. 23-653) of receptor tyrosine-protein kinase erbB-2

IL-17A - Interleukin-17A
IL-23 - Interleukin-23

JMJD2C - KDM4C or Lysine-specific demethylase 4C (a.a. 1-347)

LDHA - L-lactate dehydrogenase A chain (rabbit)

MAP2K4 - Dual specificity mitogen-activated protein kinase kinase 4

PIP4K2A kinase - Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
PDE4D - cAMP-specific 3',5'-cyclic phosphodiesterase 4D
PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
PLK4 kinase - Serine/threonine-protein kinase
PTP1B - PTPN1, Tyrosine-protein phosphatase non-receptor type 1

ROR-gamma - Nuclear receptor ROR-gamma

S100A4 - Mts1 or Protein S100-A4
S100A9 - MRP14 or Protein S100-A9
S100A12 - Protein S100-A12
SMARCA2 - bromodomain of human BRM
SMARCA4 - Transcription activator BRG1
STK10 kinase - LOK, Serine/threonine-protein kinase 10
STK17A kinase - DRAK1, Serine/threonine-protein kinase 17A
STK17B kinase - DRAK2, Serine/threonine-protein kinase 17B

Thrombin - human alpha thrombin
TIM3 - Hepatitis A virus cellular receptor 2
TNF-alpha - Tumor necrosis factor

USP7 - Ubiquitin carboxyl-terminal hydrolase 7 ((a.a. 208-554)
USP8 - Ubiquitin carboxyl-terminal hydrolase 8

Vps34 - Phosphatidylinositol 3-kinase catalytic subunit type 3

  • HSP90 crystals for X-ray crystallography
    HSP90 X-ray structure
  • PIM1 crystals for X-ray crystallography
    PIM1 X-ray structure
  • USP8 crystals
    USP8 3D structure
  • Lactate dehydogenase, LDH, crystals
    Lactate dehydogenase, LDH, crystal structure
  • Galactin 8N crystals
    Galactin 8N crystal structure
  • IL-23 crystallization
    IL-23 crystal structure

FastLane™ Standard Library

SARomics Biostructures X-ray crystallography services include a FastLane™ Standard Library of proteins. This expanding library currently includes more than 150 constructs of drug target proteins ready for expression, purification, crystallization and structure determination according to verified protocols. Among those there are more than 50 protein kinases, a large collection of phosphatases, more than 40 epigenetic targets and other proteins. Using our high-throughput X-ray crystallography pipeline, the turnaround time for structure determination is between 6 to 12 weeks depending on the protein.

Please click below to view the lists of available proteins

  • Kinases

    AK1 - Adenylate kinase isoenzyme 1 (a.a. 1-193).
    AK2 - Adenylate kinase isoenzyme 2, mitochondrial (a.a. 1-239).
    AK3L1 - Adenylate kinase isoenzyme 4, mitochondrial (1-223).
    AK5 - Adenylate kinase isoenzyme 5 (a.a. 366-562).

    BMPR2 - Bone morphogenetic protein receptor type-2 (a.a. 189-517).

    CAMK1D - Calcium/calmodulin-dependent protein kinase type 1D (a.a. 1-333).
    CAMK1G - Calcium/calmodulin-dependent protein kinase type 1G (a.a. 18-316).
    CAMK2A - Calcium/calmodulin-dependent protein kinase type II subunit alpha (a.a. 13-302).
    CAMK2B - Calcium/calmodulin-dependent protein kinase type II subunit beta (a.a. 11-303).
    CAMK2D - Calcium/calmodulin-dependent protein kinase type II subunit delta (a.a. 11-309).
    CAMK2G - Calcium/calmodulin-dependent protein kinase type II subunit gamma (a.a. 5-315).
    CAMK4 - Calcium/calmodulin-dependent protein kinase type IV (a.a. 15-340).
    CLK1 - Dual specificity protein kinase CLK1 (a.a. 148-484).
    CLK2 - Dual specificity protein kinase CLK2 (a.a. 135-496).
    CLK3 - Dual specificity protein kinase CLK3 (a.a. 284-638).
    CSNK1G1 - Casein kinase I isoform gamma-1 (a.a. 45-352).
    CSNK1G2 - Casein kinase I isoform gamma-2 (a.a. 43-353).
    CSNK1G3 - Casein kinase I isoform gamma-3 (a.a. 35-362).

    DMPK - Myotonin-protein kinase (a.a. 11-420).

    DYRK1A - Dual specificity tyrosine-phosphorylation-regulated kinase 1A (a.a. 127-485).
    DYRK2 - Dual specificity tyrosine-phosphorylation-regulated kinase 2 (a.a. 146-552).

    EphA7 - Ephrin type-A receptor 7 (a.a. 590-899)

    FLT1 (VEGFR1) - Tyrosine-protein kinase receptor FLT (a.a. 801-1158).

    GAK - Cyclin-G-associated kinase (a.a. 12-347).

    Haspin - GSG2 or Serine/threonine-protein kinase haspin (a.a. 465-798).

    ITPK1 - Inositol-tetrakisphosphate 1-kinase (a.a. 1-327).
    ITPKC - Inositol-trisphosphate 3-kinase C (a.a. 425-683).

    LOK - STK10 or Serine/threonine-protein kinase 10 (a.a. 18-317).

    MAP2K6 - Dual specificity mitogen-activated protein kinase kinase 6 (a.a. 47-334)
    MAP3K5 - Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase kinase 5), (a.a. 659-951).
    MAPK11 - Mitogen-activated protein kinase 11 (p38b), (a.a. 5-350).
    MAPK6 - Mitogen-activated protein kinase 6 (a.a. 9-327).
    MPSK1 - STK16 or Serine/threonine-protein kinase 16 (a.a. 13-305).
    MST4 - Serine/threonine-protein kinase (a.a. 1-300).
    NEK2 - Serine/threonine-protein kinase (a.a. 1-271).

    PAK4 - Serine/threonine-protein kinase PAK 4 (a.a. 291-591).
    PAK5 - Serine/threonine-protein kinase PAK 5 (a.a. 425-719).
    PAK6 - Serine/threonine-protein kinase PAK 6 (a.a. 383-681).
    PCTK1 - Cyclin-dependent kinase 16 (a.a. 163-478).

    PHKG2 - Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (a.a. 6-293).
    PIP5K2C - Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (a.a. 32-421).
    PKM2 - Pyruvate kinase isozymes (a.a. 3-530).
    PKMYT1 - Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (a.a. 75-362).
    PTK2B - Protein-tyrosine kinase 2-beta (a.a. 414-692).

    RSK1 - RPS6KA1 or p90RSK or Ribosomal protein S6 kinase alpha-1 (a.a. 413-719).

    SLK - STE20-like serine/threonine-protein kinase (a.a. 19-320).
    SRPK2 - SRSF protein kinase 2 (a.a. 51-688).

    TTK - Dual specificity protein kinase TTK (a.a. 519-808).

    VRK1 - Serine/threonine-protein kinase (a.a. 3-364).
    VRK2 - Serine/threonine-protein kinase (a.a. 14-335).
    VRK3 - Inactive serine/threonine-protein kinase VRK3 (a.a. 146-474).

    YSK1 - STK25 or Serine/threonine kinase 25 (a.a. 1-293).

  • Phosphatases

    DUSP13 - Dual specificity protein phosphatase 13 isoform B (a.a. 1-198).

    IMPA2 - Inositol monophosphatase 2 (a.a. 16-288).
    INPP5B - Type II inositol 1,4,5-trisphosphate 5-phosphatase (a.a. 339-643)
    INPP5E - 72 kDa inositol polyphosphate 5-phosphatase (a.a. 275-623).
    INPPL1 - Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (a.a. 419-732).
    ITPA - Inosine triphosphate pyrophosphatase (a.a. 1-194).

    LHPP - Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (a.a. 1-270).

    MDP1 - Magnesium-dependent phosphatase 1 (a.a. 1-165).
    MTMR6 - Myotubularin-related protein 6 (a.a. 1-505).

    NANP - N-acylneuraminate-9-phosphatase (a.a. 1-248).

    PHPT1 - 14 kDa phosphohistidine phosphatase (a.a. 5-125).
    PTPN3 - Non-receptor tyrosine-protein phosphatase type 3 (a.a. 628-913).

    PTPN4 - Non-receptor tyrosine-protein phosphatase type 4 (a.a. 611-926).
    PTPN5 - Non-receptor tyrosine-protein phosphatase type 5 (a.a. 282-563).
    PTPN7 - Non-receptor tyrosine-protein phosphatase type 7 (a.a. 65-358).
    PTPN9 (MEG2) - Non-receptor tyrosine-protein phosphatase type 9 (a.a. 277-582).
    PTPN11 - Non-receptor tyrosine-protein phosphatase type 11 (a.a. 237-533).
    PTPN14 - Non-receptor tyrosine-protein phosphatase type 14 (a.a. 886-1187).
    PTPN18 - Non-receptor tyrosine-protein phosphatase type 18 (a.a. 6-299).
    PTPN22 - Non-receptor tyrosine-protein phosphatase type 22 (a.a. 1-302).
    PTPRB - Receptor-type tyrosine-protein phosphatase beta (a.a. 1686-1971).
    PTPRE - Receptor-type tyrosine-protein phosphatase epsilon (a.a. 107-697).

    PTPRG - Receptor-type tyrosine-protein phosphatase epsilon (a.a. 827-1445).
    PTPRJ - Receptor-type tyrosine-protein phosphatase eta (a.a. 1019-1311).
    PTPRK - Receptor-type tyrosine-protein phosphatase eta (a.a. 865-1154).
    PTPRN2 - Receptor-type tyrosine-protein phosphatase N2 (a.a. 715-1010).
    PTPRO - Receptor-type tyrosine-protein phosphatase O (a.a. 916-1208).
    PTPRR - Receptor-type tyrosine-protein phosphatase R (a.a. 375-655).
    PTPRT - Receptor-type tyrosine-protein phosphatase T (a.a. 868-1151).

    RNGTT - mRNA-capping enzyme (a.a. 1-219).

    THTPA - Thiamine-triphosphatase (a.a. 1-215).

  • Epigenetic targets: Bromodomains

    ASH1L - Bromodomain, Histone-lysine N-methyltransferase ASH1L (a.a. 2438-2561).

    BAZ2B - Bromodomain adjacent to zinc finger domain protein 2B (a.a. 2054-2168).
    BPTF - Bromodomain, Nucleosome-remodeling factor subunit BPTF (a.a. 2914-3037).
    BRD1 - Bromodomain-containing protein 1 (a.a. 556-688).
    BRD9 - Bromodomain-containing protein 9 (a.a. 134-239).
    BRWD1 - Bromodomain and WD repeat-containing protein 1 (a.a. 1310-1430 Bromodomain 2).

    CECR2 - Bromodomain,, Cat eye syndrome critical region protein 2 (a.a. 424-538).
    CREBBP - Bromodomain, CREB-binding protein (a.a. 1081-1197).

    EP300 - Bromodomain, Histone acetyltransferase p300, (a.a. 1040-1161).

    KAT2A - Bromodomain, Histone acetyltransferase KAT2A, (a.a. 729-837).
    KAT2B - Bromodomain, Histone acetyltransferase KAT2B (a.a. 715-831).

    PBRM1 - Bromodomain, Protein polybromo-1 (a.a. 43-156).
    PBRM1 - Bromodomain, Protein polybromo-1 (a.a. 178-291).
    PBRM1 - Bromodomain, Protein polybromo-1 (a.a. 388-494).
    PBRM1 - Bromodomain, Protein polybromo-1 (a.a. 645-766).

    PBRM1 - Bromodomain, Protein polybromo-1 (a.a. 773-917).
    PHIP - Bromodomain, PH-interacting protein (a.a. 1302-1434).

    SMARCA4 - Bromodomain, Transcription activator BRG1 (a.a. 1448-1569).

    TAF1 - Bromodomain, Transcription initiation factor TFIID subunit 1 (a.a. 1373-1635, Bromodomains 1 & 2).
    TAF1 - Bromodomain, Transcription initiation factor TFIID subunit 1 (a.a. 1501-1635 Bromodomain 2).
    TAF1L - Bromodomain, Transcription initiation factor TFIID subunit 1-like (a.a. 1523-1654).

  • Epigenetic targets: Demethylases & others

    JMJD2A - Lysine-specific demethylase 4A (a.a. 1-359).
    JMJD2B - KDM4B or Lysine-specific demethylase 4B (a.a. 1-346).
    JMJD2C - KDM4C or Lysine-specific demethylase 4C (a.a. 875-995 tudor domains).
    JMJD2D - KDM4D or Lysine-specific demethylase 4C (a.a. 12-341).
    JMJD3 - Lysine-specific demethylase 6B (a.a.1176-1502).
    JMJD6 - Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (a.a. 1-335).

    KDM4E - KDM4DL or Lysine-specific demethylase 4E (a.a. 1-336).

    MINA - Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (a.a. 26-465).

    PHF8 - Histone lysine demethylase PHF8 (a.a. 115-483)
    PARP2 - Poly [ADP-ribose] polymerase 2 (a.a. 235-579).
    PARP3 - Poly [ADP-ribose] polymerase 3 (a.a. 178-532).
    PARP10 - Poly [ADP-ribose] polymerase 10 (a.a. 09-1017).
    PARP12 - Poly [ADP-ribose] polymerase 12(a.a. 89-684).
    PARP14 - Poly [ADP-ribose] polymerase 14(a.a. 1611-1801)
    PARP15 - Poly [ADP-ribose] polymerase 15 (a.a. 459-656).

    TNKS - Tankyrase-1 (a.a. 1091-1325).
    TNKS2 - Tankyrase-2 (a.a. 946-1152).

    ZC3HAV1 - Zinc finger CCCH-type antiviral protein 1 (a.a. 724-896).

  • Others

    ARNT - Aryl hydrocarbon receptor nuclear translocator (a.a. 356-470).

    BAK1 - Bcl-2 homologous antagonist/killer, mitochondrial apoptosis regulator (a.a. 21-190).
    BCL2A1 - Bcl-2-related protein A1 (a.a. 1-149).

    DPP4 - Dipeptidyl peptidase 4
    EPAS1 - Hif2a or Endothelial PAS domain-containing protein 1 (a.a. 239-350).

    GLS - Glutaminase kidney isoform, mitochondrial (a.a. 221-533).
    GMPR2 - GMP reductase 2 (a.a. 10-341).

    MTH1 -  NUDT1 or 7,8-dihydro-8-oxoguanine triphosphatase (a.a. 42-197).

    NT5C2 - Cytosolic purine 5'-nucleotidase (a.a. 1-536).
    NT5C3 - Cytosolic 5'-nucleotidase 3A (a.a. 64-336).
    NUDT3 - Diphosphoinositol polyphosphate phosphohydrolase 1 (a.a. 1-172).
    NUDT6 - Nucleoside diphosphate-linked moiety X motif 6 (a.a. 141-316).
    NUDT10 - Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (a.a. 17-144).

    NUDT14 - Uridine diphosphate glucose pyrophosphatase (a.a. 28-222).
    NUDT16 - U8 snoRNA-decapping enzyme (a.a. aa1-aa195).
    NUDT16L1 - Protein syndesmos (a.a.6-211)
    NUDT18 - 8-oxo-dGDP phosphatase NUDT18 (a.a. 26-179).
    NUDT21 - Cleavage and polyadenylation specificity factor subunit 5 (a.a.21-227).

    PHGDH - D-3-phosphoglycerate dehydrogenase (a.a 4-314).

    PSAT1 - Phosphoserine aminotransferase (a.a. 17-370).

    PPARG - Peroxisome proliferator-activated receptor gamma (a.a. 232-505).
    PYCR1 - Pyrroline-5-carboxylate reductase 1, mitochondrial (a.a. 1-300).

    ROR-gamma - Nuclear receptor ROR-gamma.

    THEM2 - Acyl-coenzyme A thioesterase 13 (a.a. 19-140).

    USP2 - Ubiquitin carboxyl-terminal hydrolase 2 (a.a. 258-605).
    USP5 - Ubiquitin carboxyl-terminal hydrolase 5 (a.a. 163-291).

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Gene-to-Structure Services

Gene-to-Structure services at SARomics Biostructures include cloning, expression, purification and characterization of a protein using biophysical methods, followed by crystallization and high resolution X-ray structure determination. For the most optimal handling high-throughput protocols developed at the company are used throughout the whole process.

Gene-to-Structure services are performed on a fee-for-service basis and include:
• Cloning, expression and purification of the protein
• Biophysical characterization of the protein using dynamic light scattering (DLS), CD spectroscopy, differential scanning fluorimetry (DSF), and if required, NMR spectroscopy.
• Crystallization of the protein, X-ray data collection and protein structure determination.
• Protein-ligand co-crystallization and structure determination.
More details on the methods used can be found in our technology pages.

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