SARomics Biostructures contributes to fundamental understanding of ligand and water binding to a protein

SARomics Biostructures recently contributed to an exciting article in Biochemistry where ultra-high resolution X-ray crystallography was combined with a plethora of complementary biophysical and theoretical techniques such as NMR, ITC and molecular dynamics simulations to probe the nature of water binding and hydrogen bonding in the active site of the medically important carbohydrate binding protein galectin-3. The results showed that the ligand binding site of Gal3C is highly pre-organized to…

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